Professor of Neuropathology and Chair of the Institute of Neuropathology at the University of Freiburg, Germany.
Dr. Prinz obtained his MD at the Charitè, Humboldt-University Berlin in 1997. During his MD thesis he investigated the pathology of cortical interneurons in humans at the Institute of Neuroanatomy at the Charitè Berlin. He did a postdoc at the Max-Delbrück-Centre (MDC) of Molecular Medicine dedicated to the function of glial cells in the central nervous system (CNS), especially microglia. He performed his residency in Neuropathology at the University Hospital Zurich, Switzerland and studied there the role of the peripheral and CNS-restricted immune system for the pathogenesis of neurodegenerative diseases such as prion diseases. In 2003 he became a group leader at the University Hospital in Göttingen, Germany and in 2007 lecturer of Neuropathology there.
He was recruited to the University of Freiburg, Germany, in 2008 and was promoted to the rank of Full Professor and Chair of the Institute of Neuropathology.
Dr. Prinz laboratory studies the mechanisms that regulate the development and function of the mononuclear phagocyte lineage in the central nervous system including microglia, perivascular and meningeal macrophages. His laboratory has made seminal discoveries in CNS macrophage biology revealing their embryonic origin and their local maintenance in situ. Dr. Prinz belongs to several German Research Foundation (DFG)- and EU-funded scientific consortia to decipher the transcriptional regulation of the macrophage lineage in the CNS.
Currently, his research group aims to understand myeloid cell biology in the CNS during health and disease and studies the impact of the immune system on the pathogenesis of neurological disorders such as neurodegenerative diseases, ultimately aimed at recognizing novel therapeutic strategies and targets to treat these central nervous system diseases.
Dr. Prinz has authored more than 170 primary papers and reviews in high profile journals and has obtained extensive DFG and EU funding for his studies on macrophage biology in the CNS in mice and humans.